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A complete of three % of Energetic substance is excreted in urine as unchanged active material. Tapentadol is Also metabolised to N-desmethyl tapentadol (thirteen %) by CYP2C9 and CYP2C19 also to hydroxy tapentadol (two %) by CYP2D6, which are even further metabolised by conjugation. As a result, Lively material metabolism mediated by cytochrome P4